Union Mills are all but relegated from the Canada Life Premier League after losing to Colby on Saturday afternoon.
The Millers knew they needed to be the Moonlighters to stand a realistic - if slim - chance of beating the drop to JCK Division Two.
However, a stunning strike from Andy Blake plus a Jim Collett goal put Colby 2-0 up at half-time at the Station Fields.
Mills improved after the break but fell further behind when Jordan Primrose-Smith chipped home a third before Blake grabbed his second of the afternoon with another fine strike.
The visitors pulled a goal back through Chris Kelly but it proved too little too late and the Millers now need a remarkable turnaround - including wins against Peel and Corinthians - if they are to pull off the Great Escape.
The result of the day belonged to Douglas Athletic who stunned St Mary’s in the Friends Provident International FA Cup quarter-finals.
Goals from Mikey Callister, Martin Cowan and Darren Shields meant that the game at Springfield Road appeared destined for extra-time.
That was until Connor Dowell - back from his travels - grabbed a dramatic 94th minute winner on his first team return to send the Pinks faithful into dreamland and book their place in the semi-finals.
Douglas and District narrowly missed out on joining DAFC in the last four as they were narrowly beaten away at promotion-chasing Foxdale in a match played at the Bowl.
Charlie Harrison and Jay Chatwood put Dale in the driving seat only for D&D to produce a stirring comeback, helped by Darren Armstrong saving Aaron Costain’s penalty.
Daniel Clague-Stewart then halved the deficit in the 69th minute for the Noble’s Park outfit to give them hope but Foxdale were able to hold their nerve and see out the remainder of the game to book their place in the semis.
They will be joined by Peel who thrashed Division Two promotion hopefuls Braddan 8-1 at the Station Fields.
The westerners were in cruise control at their second home, racing into an early 3-0 lead thanks to goals from Dominic McGreevy, Ryan Holdaway and Daniel Bell.
After half-time the Sunset City side added further goals from Tom Wood, Ash Webster - his 99th for the club - Billy Kennaugh, Marc Kelly and an own goal sealed an emphatic win. Spicer grabbed the consolation strike for the Swans.
Douglas Royal’s hopes of a treble were ended by an impressive Castletown who beat the Whites 4-1 in the GH Corlett Woods Cup quarter-finals.
The Mets raced into a two-goal lead at half-time before Chris Anderson pulled one back for Royal almost immediately after the restart, however two more goals from the southerners sealed a fine win for Town.
Elsewhere in the Canada Life Premier League, Corinthians boosted their hopes of finishing second with a good 3-1 victory away at St John’s while two late goals from Craig Murphy and Josh Thomas sealed a 2-0 win for DHSOB at Laxey.
The sole game in JCK Division Two saw Marown romp to a 7-0 victory at home to Malew, a result which moves them up to sixth in the league table.
Football results for Saturday, March 18
Friends Provident FA Cup quarter-finals
Douglas Athletic 4-3 St Mary’s
Foxdale 2-1 Douglas & District
Peel 8-1 Braddan
GH Corlett Woods Cup quarter-final
Castletown 4-1 Douglas Royal
Canada Life Premier League
Colby 4-1 Union Mills
Laxey 0-2 DHSOB
St John’s 1-3 Corinthians
JCK Division Two
Marown 7-0 Malew
Canada Life Combination One
St George’s 2-0 Peel
Union Mills 1-5 Corinthians
JCK Combination Two
Douglas Royal 3-1 Michael Utd